ePillz.com - Cialis Reduces Damages from Heart Attack

Cialis Reduces Damages from Heart Attack

January, 2007 - International Journal of Impotence Research –

Cialis (tadalafil) demonstrated the ability to reduce the myocardial infarct size (death of heart muscle cells after the heart attack) in the first animal model clinical trial, conducted by the Heart Institute, University of Southern California and Good Samaritan Hospital, USA with participation of ICOS Corporations and Lilly Research Laboratories. The information on this finding was published in the January/February, 2007 issue of the International Journal of Impotence Research.

Cialis is the newest medication, approved by the American Food and Drug Administration to treat male erectile dysfunction. The medicine belongs to the group of enzyme phosphodiesterase-5 (PDE5) inhibitors, but in comparison to other representatives of this class of medications (Viagra and Levitra) Cialis has the longest period of action, which allows it to stay effective for as long as 36 hours. Since there was no data on the effect of tadalafil in the situation of coronary arteries occlusion, the scientists decided to compare the consequences of heart attack in animals (rats), treated with tadalafil, and untreated ones.

Erectile dysfunction (ED) is a very widely-spread disease: about 200 million men worldwide suffer from the illness. Very often ED is the early sign of cardiovascular disease development, because patients with ED have a lot of risk factors, contributing to the development of heart problems, such as heart attack. The most significant risks include smoking, obesity, diabetes, high blood pressure and high level of cholesterol in blood.

Heart attack or myocardial infarction is a life-threatening condition, when one of the coronary arteries, which supply heart with blood and oxygen, are partially or complete blocked with blood clot. The reduction of blood stream in the heart muscle results in the death of heart cells. In absence of urgent medical help, this may lead to patient death. The severity of heart attack depends on the size of damaged (dead) area of the heart. That is why it is vitally important to reduce the size of myocardial infarct size.

To find out the impact of tadalafil on the infarct size, the scientists modeled the situation of heart attack in the laboratory rats and then checked the size of damaged areas in both groups of animals. The trial results showed the significant difference 42% vs. 54% in the size of damaged heart area between those rats that received tadalafil prior to heart attack and those animals that did not receive the medication.

So, the conducted animal trial showed that tadalafil (the active ingredient of Cialis) caused the significant reduction in the percentage of necrosis (cell death) due to heart attack in the animal models. For the first time the researchers demonstrated that tadalafil can play the cardio-protective role by significant reduction of heart muscle cells death in the setting of acute coronary artery occlusion. For people, using Cialis as the treatment of erectile dysfunction, this finding means that the medication not only helps to restore their sexual performance, but also may protect their hearts from devastating consequences of myocardial infarction.

Nick

External resources
http://www.nature.com/ijir/index.html
http://www.nature.com/ijir/journal/v19/n1/full/3901497a.html
http://www.amazon.com/American-Medical-Association-Complete-Encyclopedia/dp/0...